Science-backed peptides for appetite control, metabolic health, and sustainable weight management
Peptides are short chains of amino acids that act as signaling molecules in your body. When it comes to diet and weight management, specific peptides can dramatically improve your results by targeting the root causes of weight gain: excessive appetite, slow metabolism, and poor nutrient partitioning.
Type: GLP-1 receptor agonist
Weight loss: 15-17% average
Best for: Significant weight loss, appetite control, blood sugar management
How it works: Mimics GLP-1 hormone to slow gastric emptying, reduce appetite, and improve insulin sensitivity
Dosing: Weekly injection, gradual titration from 0.25mg to 2.4mg
Type: Dual GIP/GLP-1 agonist
Weight loss: 20-21% average
Best for: Maximum weight loss, superior appetite control, metabolic health
How it works: Activates both GIP and GLP-1 receptors for enhanced effects on appetite, metabolism, and fat loss
Dosing: Weekly injection, titration from 2.5mg to 15mg
Type: GLP-1 receptor agonist
Weight loss: 8-10% average
Best for: Daily dosing option, gradual weight loss, diabetes management
How it works: Similar to semaglutide but shorter-acting, requires daily injection
Dosing: Daily injection, titration from 0.6mg to 3.0mg
Type: Modified growth hormone fragment
Fat loss: Targets stubborn fat deposits
Best for: Fat loss without appetite suppression, body recomposition
How it works: Stimulates lipolysis (fat breakdown) without affecting blood sugar or growth
Dosing: 300mcg daily, typically in morning fasted
Type: NNMT inhibitor
Metabolic boost: Increases NAD+ levels
Best for: Metabolic enhancement, energy increase, fat oxidation
How it works: Inhibits NNMT enzyme to boost cellular metabolism and fat burning
Dosing: 50-100mg daily, oral or injectable
Type: Mitochondrial peptide
Metabolic effects: Enhances insulin sensitivity
Best for: Metabolic health, insulin resistance, energy production
How it works: Regulates metabolic homeostasis and improves glucose metabolism
Dosing: 5-15mg, 2-3x weekly
| Peptide | Weight Loss | Appetite Control | FDA Status | Monthly Cost |
|---|---|---|---|---|
| Tirzepatide | 20-21% (Best) | Excellent | ✅ Approved | $1,000-1,400 |
| Semaglutide | 15-17% (Excellent) | Excellent | ✅ Approved | $900-1,300 |
| Liraglutide | 8-10% (Good) | Good | ✅ Approved | $1,200-1,500 |
| AOD-9604 | 5-8% (Moderate) | None | ❌ Research | $150-250 |
| 5-Amino-1MQ | 3-5% (Mild) | None | ❌ Research | $100-200 |
| MOTS-c | 2-4% (Mild) | None | ❌ Research | $200-300 |
Why it works: GLP-1 peptides make fasting effortless by eliminating hunger. Many users naturally fall into 16:8 or 18:6 fasting windows.
Protocol:
Expected results: 2-3 lbs per week fat loss, minimal hunger, preserved muscle mass
Why it works: Protein is the most satiating macronutrient. Combined with metabolic peptides, you maximize fat loss while building/maintaining muscle.
Protocol:
Expected results: 1-2 lbs per week fat loss, muscle preservation or growth, improved body composition
Why it works: Low-carb diets naturally reduce appetite. GLP-1 peptides amplify this effect for powerful fat loss.
Protocol:
Expected results: 2-4 lbs per week initially, 1-2 lbs weekly after adaptation, significant appetite suppression
Why it works: Alternating high and low calorie days prevents metabolic adaptation while maintaining fat loss.
Protocol:
Expected results: 1-1.5 lbs per week fat loss, maintained energy levels, preserved metabolism
When using appetite-suppressing peptides, it's crucial to prioritize protein to prevent muscle loss:
Reduced calorie intake means you need nutrient-dense foods:
Consider these supplements when using diet peptides:
Explore detailed guides, protocols, and calculators to optimize your weight loss journey
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