How peptides optimize metabolic function for maximum fat burning and energy
Your metabolism is the sum of all chemical processes that convert food into energy. A faster metabolism means you burn more calories at rest, making weight loss easier and weight maintenance effortless. Certain peptides can significantly enhance metabolic function through multiple pathways.
Mechanism: NNMT inhibitor that increases NAD+ levels
Metabolic boost: 10-15% increase in resting metabolic rate
How it works: Blocks NNMT enzyme, allowing NAD+ to accumulate. Higher NAD+ = more efficient cellular metabolism and fat oxidation.
Benefits:
Dosing: 50-100mg daily, oral or injectable
Duration: 8-12 weeks for optimal results
Mechanism: Mitochondrial-derived peptide that regulates metabolism
Metabolic boost: Improves glucose metabolism and insulin sensitivity
How it works: Regulates metabolic homeostasis, enhances mitochondrial function, and improves how your body uses glucose and fat for energy.
Benefits:
Dosing: 5-15mg, 2-3x weekly
Duration: 4-8 weeks, can cycle long-term
Mechanism: Modified growth hormone fragment that targets fat cells
Metabolic boost: Stimulates lipolysis without affecting blood sugar
How it works: Mimics the fat-burning effects of growth hormone without the growth-promoting or insulin-affecting properties.
Benefits:
Dosing: 300mcg daily, preferably in morning fasted
Duration: 12-16 weeks for best results
Mechanism: GHRH analog that increases growth hormone
Metabolic boost: Reduces visceral fat, increases lean mass
How it works: Stimulates natural GH production, which enhances fat metabolism and preserves muscle during calorie restriction.
Benefits:
Dosing: 2mg daily before bed
Duration: 12-26 weeks for maximum visceral fat loss
| Peptide | Primary Mechanism | Metabolic Boost | Best For | Monthly Cost |
|---|---|---|---|---|
| 5-Amino-1MQ | NAD+ increase | 10-15% RMR increase | Overall metabolism, energy | $100-200 |
| MOTS-c | Mitochondrial function | Insulin sensitivity | Glucose metabolism, exercise | $200-300 |
| AOD-9604 | Lipolysis stimulation | Direct fat burning | Stubborn fat, body recomp | $150-250 |
| Tesamorelin | GH increase | Visceral fat reduction | Belly fat, body composition | $400-600 |
| CJC-1295 + Ipa | GH optimization | Comprehensive metabolic | Muscle preservation, fat loss | $250-400 |
Peptides: 5-Amino-1MQ + AOD-9604 + MOTS-c
Protocol:
Expected results: 15-20% increase in metabolic rate, 2-3 lbs fat loss per week, significant energy increase
Duration: 12 weeks, then 4-week break
Cost: $400-550/month
Peptides: CJC-1295 + Ipamorelin + AOD-9604
Protocol:
Expected results: Fat loss + muscle gain simultaneously, improved body composition, enhanced recovery
Duration: 16 weeks
Cost: $350-500/month
Peptides: MOTS-c + 5-Amino-1MQ
Protocol:
Expected results: Reversed insulin resistance, better glucose control, enhanced fat burning, increased energy
Duration: 8-12 weeks
Cost: $300-400/month
Building muscle is the #1 way to permanently increase metabolism. Muscle tissue burns 3x more calories than fat tissue at rest.
High-intensity interval training creates an "afterburn effect" (EPOC) that elevates metabolism for 24-48 hours post-workout.
Poor sleep destroys metabolism. Just one night of bad sleep can reduce insulin sensitivity by 30%.
Cold activates brown fat, which burns calories to generate heat.
Caffeine can boost metabolism by 3-11% and enhance fat oxidation.
1. Resting Metabolic Rate (RMR) Testing
2. Online Calculators (Estimates)
3. Wearable Devices
4. Body Composition Changes
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